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Losartan Potassium

Losartan Potassium

CAS: 124750-99-8

Molecular Formula: C22H23ClKN6O

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Losartan Potassium - Names and Identifiers

Name Losartan Potassium
Synonyms MK 954
Losartan Potassium
LOSARTAN POTASSIUM
LOSARTAN POTASSIUM SALT
LOSARTAN MONOPOTASSIUM SALT
1h-imidazole-5-methanol,2-butyl-4-chloro-1-((2'-(1h-tetrazol-5-yl)(1,1'-biphe
2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL
potassium (2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanolate
potassium 5-(4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}biphenyl-2-yl)tetrazol-1-ide
2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT
2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt
CAS 124750-99-8
EINECS 200-287-4
InChI InChI=1/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12H,2-3,8,13-14H2,1H3,(H,25,26,27,28);/q-1;+1
InChIKey OXCMYAYHXIHQOA-UHFFFAOYSA-N

Losartan Potassium - Physico-chemical Properties

Molecular FormulaC22H23ClKN6O
Molar Mass462.01
Melting Point263-265°C
Boling Point682°C at 760 mmHg
Flash Point366.3°C
Solubility Soluble in water (>500 mg/ml), PBS (pH 7.2) (≥10 mg/ml), ethanol (≥20 mg/ml), DMSO (10
Vapor Presure1.55E-19mmHg at 25°C
AppearanceWhite to yellowish powder
ColorOff-white
Merck14,5583
BRN5845770
Storage ConditionInert atmosphere,Room Temperature
StabilityStable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
MDLMFCD02092704
UseA specific antagonist of the AT1 receptor with significant downstream effects.
In vivo studyIn monkeys with diet-induced hypercholesterolemia, Losartan(180 mg/day) caused a significant increase in plasma angiotensin II and angiotensin-(1-7). In monkeys with diet-induced hypercholesterolemia, Losartan(180 mg/day) reduced approximately 50% of the extent of fatty striae in the aorta, coronary arteries, and carotid arteries. In monkeys with diet-induced hypercholesterolemia, Losartan reduced the susceptibility to in vitro oxidation of low-density lipoprotein, serum levels of monocyte chemoattractant protein -1, and expression of circulating monocyte CD11b. In pregnant fbn1-apolipoprotein E-deficient mice, Losartan(5 mg/kg/day) caused a significant decrease in the development of atherosclerotic lesions. In apolipoprotein E-deficient mice, Losartan(5 mg/kg/day) significantly reduced the sensitivity of mouse LDL to fat oxidation after incubation in the presence of cuso4. In male Sprague Dawley rats, Losartan (10 mg/kg) administration increased angiotensin levels 4-to 6-fold without altering blood BK levels. In male Sprague Dawley rats, Losartan (10 mg/kg) increased plasma renin levels 100-fold and plasma angiotensin levels were reduced to 24% of controls without altering plasma aldisterol levels.

Losartan Potassium - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany3
RTECSNI6755100
HS Code2933290000

Losartan Potassium - Nature

Open Data Verified Data

white or off-white flowable crystalline powder. Very soluble in water, soluble in methanol or ethanol, slightly soluble in acetonitrile, methyl ethyl ketone and other general organic solvents, almost insoluble in chloroform.

Last Update：2024-01-02 23:10:35

Losartan Potassium - Preparation Method

Open Data Verified Data

2-butyl -4-chlorine 5-hydroxymethyl imidazole and sodium methoxide methanol solution stirring reaction, the formation of sodium salt and 4 '-bromomethyl-2-cyanobiphenyl in dimethylformamide, the obtained compound is etherified and then reacted with sodium azide in dimethylformamide containing ammonium chloride to obtain losartan by acidic hydrolysis.

Last Update：2022-01-01 09:10:42

Losartan Potassium - Use

Open Data Verified Data

Cozaar was first launched in 1994 and is currently approved in 93 countries for the treatment of hypertension. Oral administration of non-peptide angiotensin II receptor antagonists. Mainly used for primary hypertension. Cozaar is the first angiotensin II receptor antagonist (AIIA) class of antihypertensive drugs.

Last Update：2022-01-01 09:10:42
Losartan Potassium
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Guangzhou Yuanda New Material Co.,Ltd
Product Name: Losartan potassium Request for quotation
CAS: 124750-99-8
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
Wechat: +86 19849939632
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Losartan Potassium Salt Visit Supplier Webpage Request for quotation
CAS: 124750-99-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Losartan Potassium Request for quotation
CAS: 124750-99-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Losartan potassium Visit Supplier Webpage Request for quotation
CAS: 124750-99-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Zouping Mingxing Chemical Co., Ltd.
Product Name: Losartan potassium Request for quotation
CAS: 124750-99-8
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
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Losartan Potassium
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